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In this article, empirical analysis of the effects of forced convection and Darcy friction factorise done using nano-fluid and downward flow in negative incline tube. This can be affected by boundary condition when the flow regime was fully developed and laminar, and wall temperature was isothermal. The use of nano-fluid, negative slope can have effect on the augmentation of forced convection. Two equations have been strongly suggested to be estimate the forced convection and pressure drop in a downward flow. The peaked deflection of isothermal and Darcy friction factor are 20% and 21% respectively. The results show that the use of equation is appropriate as long as these are used in experimental investigation. In addition forced convection ratio with ratio of pressure drop is calculated. As long as the rise of figure of merit is more than a unit, It is no longer suitable to apply CuO-TO nano-fluid, minus slopes and micro fine pipe. The maximum FOM is 1.59% extracted with 1.5% weight fraction and slope of 60ºat Prandtl number of 310. The upshots illustrate majority of the quantities is more than a unit, and as a consequences the heat transfer improvement is more than rise of pressure drop.
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