Definition of Irritable bowel syndrome (IBS) is a functional bowel disorder characterized by altered bowel habits and pain or discomfort in the abdomen without detectable structural abnormalities. In IBS severity of symptoms varies and can significantly impair quality of life, resulting in high health care costs. This study systematically reviewed the published clinical research in PubMed on Ayurvedic medicines and their reliable mechanisms of action in controlling IBS. Rather the combinations of single-drug formulations mentioned in our classical textbooks may be more effective. And different clinical trials must be needed to evaluate the effects of Ayurvedic preparations on IBS.